Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells.

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dc.contributor.author Moodley, K.
dc.contributor.author Weiss, S.F.T.
dc.date.accessioned 2016-10-24T13:08:12Z
dc.date.available 2016-10-24T13:08:12Z
dc.date.issued 2013-03-05
dc.identifier.citation Moodley, K. and Weiss, S.F.T. 2013. Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells. PLoS ONE 8(3):e57409. en_ZA
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10539/21254
dc.description.abstract The non-integrin laminin receptor, here designated the 37-kDa/67-kDa laminin receptor (LRP/LR), is involved in many physiologically relevant processes, as well as numerous pathological conditions. The overexpression of LRP/LR on various cancerous cell lines plays critical roles in tumour metastasis and angiogenesis. This study investigated whether LRP/LR is implicated in the maintenance of cellular viability in lung and cervical cancer cell lines. Here we show a significant reduction in cellular viability in the aforementioned cell lines as a result of the siRNA-mediated downregulation of LRP. This reduction in cellular viability is due to increased apoptotic processes, reflected by the loss of nuclear integrity and the significant increase in the activity of caspase-3. These results indicate that LRP/LR is involved in the maintenance of cellular viability in tumorigenic lung and cervix uteri cells through the blockage of apoptosis. Knockdown of LRP/LR by siRNA might represent an alternative therapeutic strategy for the treatment of lung and cervical cancer. en_ZA
dc.description.sponsorship NRF, South Africa. MRC, South Africa. en_ZA
dc.language.iso en en_ZA
dc.publisher Public Library of Science. en_ZA
dc.rights © 2013 Moodley, Weiss. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_ZA
dc.subject 37 kDa laminin receptor precursor en_ZA
dc.subject 67 kDa laminin receptor en_ZA
dc.subject caspase 3 en_ZA
dc.subject laminin receptor en_ZA
dc.subject small interfering RNA en_ZA
dc.subject unclassified drug en_ZA
dc.subject apoptosis en_ZA
dc.subject cancer cell en_ZA
dc.subject cell nucleus en_ZA
dc.subject cell surface en_ZA
dc.subject Cell Line en_ZA
dc.subject Tumor en_ZA
dc.subject Cell Survival en_ZA
dc.subject Down-Regulation en_ZA
dc.subject Enzyme Activation en_ZA
dc.subject Female en_ZA
dc.subject Gene Expression Regulation en_ZA
dc.subject Neoplastic en_ZA
dc.subject HeLa Cells en_ZA
dc.subject Humans en_ZA
dc.subject Lung Neoplasms en_ZA
dc.subject Receptors en_ZA
dc.subject Laminin en_ZA
dc.subject RNA en_ZA
dc.subject Uterine Cervical Neoplasms en_ZA
dc.title Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells. en_ZA
dc.type Article en_ZA
dc.journal.volume 8 en_ZA
dc.journal.title PLoS ONE en_ZA
dc.description.librarian NCS2016 en_ZA
dc.citation.doi 10.1371/journal.pone.0057409 en_ZA
dc.citation.issue 3 en_ZA


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