Reversible phosphorylation of proteins in proliferating and differentiating cells: cyclic variations and the effect of growth regulators

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dc.contributor.author Ferreira, Gracinda Maria Nunes
dc.date.accessioned 2017-07-20T13:00:03Z
dc.date.available 2017-07-20T13:00:03Z
dc.date.issued 1994
dc.identifier.citation Ferreira, Gracinda Maria Nunes (1994) Reversible phosphorylation of proteins in proliferating and differentiating cells: cyclic variations and the effect of growth regulators, University of the Witwatersrand, Johannesburg,<http://hdl.handle.net/10539/23022>
dc.identifier.uri http://hdl.handle.net/10539/23022
dc.description A Dissertation Submitted to the Faculty of Science University of the Witwatersrand, Johannesburg In fulfilment of the requirements for the Degree of Doctor of Philosophy Johannesburg 1994 en_ZA
dc.description.abstract Living cells are highly auto-dynamic entities which means that the underlying biochemistry is equally dynamic, a reality which is ignored by most researchers. Theoretical studies indicate that such a state must be due to the existence of oscillatory variations in the levels and activities of key components in the cell. In this study, the dynamic behaviour of four major, interrelated areas of cell biochemistry (phosphorylation, dephosphorylation, the terminal reaction of glycolysis and the amount of soluble protein) were examined and all systems found to oscillate in murine erythroleukaemic cells (MEL) and, where examined, also in the human HL-6Q leukaemic cell line. [Abbreviated Abstract. Open document to view full version]
dc.format.extent Online resource (374 leaves)
dc.language.iso en en_ZA
dc.subject.lcsh Protein kinases
dc.subject.lcsh Phosphorylation
dc.subject.lcsh Growth regulators
dc.title Reversible phosphorylation of proteins in proliferating and differentiating cells: cyclic variations and the effect of growth regulators en_ZA
dc.type Thesis en_ZA
dc.description.librarian MT2017 en_ZA


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