Reversible phosphorylation of proteins in proliferating and differentiating cells : cyclic variations and the effect of growth regulators / Gracinda Maria Nunes Ferreira.

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dc.contributor.author Ferreira, Gracinda Maria Nunes
dc.date.accessioned 2018-04-20T07:58:31Z
dc.date.available 2018-04-20T07:58:31Z
dc.date.issued 1994
dc.identifier.uri https://hdl.handle.net/10539/24375
dc.description A Dissertation Submitted to the Faculty of SCience University of the Witwatersrand, Johannesburg In fulfilment of the requirements for the Degree of Doctor of Philosophy en_ZA
dc.description.abstract Living cells are highly auto-dynamic entities which means that the underlying biochemistry is equally dynamic, a reality which is ignored by most researchers. Theoretical studies indicate that such a state must be due to the existence of oscillatory variations in the levels and activities of key components in the cell. In this study, the dynamic behaviour of four major, interrelated areas of cell biochemistry (phosphorylation, dephosphorylation, the terminal reaction of glycolysis and the amount of soluble protein) were examined and all systems found to oscillate in murine erythroleukaemic cells (MEL) and, where examined, also in the human HL-60 leukaemic cell line. (Abbreviation abstract) en_ZA
dc.language.iso en en_ZA
dc.subject Protein kinases. en_ZA
dc.subject Phosphorylation. en_ZA
dc.subject Growth regulators en_ZA
dc.title Reversible phosphorylation of proteins in proliferating and differentiating cells : cyclic variations and the effect of growth regulators / Gracinda Maria Nunes Ferreira. en_ZA
dc.type Thesis en_ZA
dc.description.librarian AC 2018 en_ZA


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