Growth regulation by heparin in the vascular wall

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dc.contributor.author Karnovsky, Morris, John
dc.date.accessioned 2018-10-15T10:50:46Z
dc.date.available 2018-10-15T10:50:46Z
dc.date.issued 1983-06-10
dc.identifier.uri https://hdl.handle.net/10539/25806
dc.description A Thesis Submitted to the Faculty of Medicine University of the Witwatersrand, Johannesburg in fulfillment of the requirements for the Degree of Doctor of Science in Medicine Boston, U.S.A. 1983 en_ZA
dc.description.abstract Vascular smooth muscle proliferation follows upon endothelial injury, and is thought to be an early component in the pathogenesis of atherosclerosis, and a possible noxious consequence of vascular surgery. We have shown that heparin suppresses vascular smooth muscle proliferation iri vivo and in vitro. The inhibitory effect is specific for heparin, and not other anions, and is not related to the antithrombin III binding activity of heparin. It is dependent on the size of the molecule, (hexasaccharidees or smaller being ineffective), and O-sulfation, but not N-sulfation en_ZA
dc.language.iso en en_ZA
dc.subject.mesh Heparin
dc.subject.mesh In Vitro Techniques
dc.subject.mesh Muscle, Smooth, Vascular
dc.title Growth regulation by heparin in the vascular wall en_ZA
dc.type Thesis en_ZA
dc.description.librarian IT2018 en_ZA


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