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Browsing School of Molecular & Cell Biology by Issue Date

Browsing School of Molecular & Cell Biology by Issue Date

Now showing items 1-14 of 14

Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells.

Moodley, K.; Weiss, S.F.T. (Public Library of Science., 2013-03-05)

The non-integrin laminin receptor, here designated the 37-kDa/67-kDa laminin receptor (LRP/LR), is involved in many physiologically relevant processes, as well as numerous pathological conditions. The overexpression of ...
In Vitro Inhibition of Angiogenesis by Antibodies Directed against the 37kDa/67kDa Laminin Receptor

Khusal, R.; Da Costa Dias, B; Moodley, K.; Penny, C.; Reusch, U.; Knackmuss, S.; Little, M.; Weiss, S.F.T. (Public Library of Science, 2013-03-12)

The 37kDa/67kDa laminin receptor (LRP/LR) is a central receptor mediating interactions between tumour cells and the basement membrane and is thereby a key player in adhesion and invasion, essential processes in metastatic ...
Adhesion and Invasion of Breast and Oesophageal Cancer Cells Are Impeded by Anti-LRP/LR-Specific Antibody IgG1-iS18.

Khumalo, T.; Reusch, U.; Knackmuss, S.; Little, M.; Veale, R.B.; Weiss, S.F.T. (Public Library of Science., 2013-06-18)

Adhesion and invasion have been identified as the two key components of metastasis. The 37 kDa/67 kDa laminin receptor (LRP/LR) is thought to enhance these two processes thus endorsing the progression of cancer. Here we ...
Assessing Global Transcriptome Changes in Response to South African Cassava Mosaic Virus [ZA-99] Infection in Susceptible Arabidopsis thaliana.

Pierce, E.J.; Rey, M.E.C. (Public Library of Science., 2013-06-27)

In susceptible plant hosts, co-evolution has favoured viral strategies to evade host defenses and utilize resources to their own benefit. The degree of manipulation of host gene expression is dependent on host-virus ...
Anti-LRP/LR specific antibody IgG1-iS18 impedes adhesion and invasion of liver cancer cells.

Khumalo, T.; Reusch, U.; Knackmuss, S.; Little, M.; Weiss, S.F.T.; Chetty, C.; Da Costa Dias, B. (Public Library of Science., 2014-05-05)

Two key events, namely adhesion and invasion, are pivotal to the occurrence of metastasis. Importantly, the 37 kDa/67 kDa laminin receptor (LRP/LR) has been implicated in enhancing these two events thus facilitating cancer ...
High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.

Jovanovic, K.; Loos, B.; Da Costa Dias, B.; Penny, C.; Weiss, S.F.T. (Public Library of Science., 2014-06-27)

Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid ...
Evaluation of Physicochemical Properties of South African Cashew Apple Juice as a Biofuel Feedstock.

Deenanath, E.D.; Rumbold, K.; Daramola, M.; Falcon, R.; Iyuke, S. (Hindawi Publishing Corp, 2015)

Cashew apple juice (CAJ) is one of the feedstocks used for biofuel production and ethanol yield depends on the physical and chemical properties of the extracted juice. As far as can be ascertained, information on physical ...
The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning.

Hull, R.; Oosthuysen, B.; Cajee, U.-F.; Mokgohloa, L.; Nweke, E.; Antunes, R.J.; Coetzer, T.H.T.; Ntwasa, M. (MDPI AG, 2015-05)

The human retinoblastoma binding protein 6 (RBBP6) is implicated in esophageal, lung, hepatocellular and colon cancers. Furthermore, RBBP6 was identified as a strong marker for colon cancer prognosis and as a predisposing ...
Overexpression, purification and characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) protein.

Zininga, T.; Hoppe, H.C.; Prinsloo.E.; Dirr, H.W.; Shonhai, A.; Achilonu, I. (Public Library of Science., 2015-06-17)

Six Hsp70-like genes are represented on the genome of Plasmodium falciparum. Of these two occur i0n the cytosol: P. falciparum Hsp70-z (PfHsp70-z) and PfHsp70-1. PfHsp70-1 is a well characterised canonical Hsp70 that ...
Knockdown of LRP/LR Induces Apoptosis in breast and oesophageal cancer cells.

Khumalo, T.; Ferreira, E.; Jovanovic, K.; Veale, R.B.; Weiss, S.F.T. (2015-10-01)

Cancer is a global burden due to high incidence and mortality rates and is ranked the second most diagnosed disease amongst non-communicable diseases in South Africa. A high expression level of the 37kDa/67kDa laminin ...
Knock-down of the 37kDa/67kDa laminin receptor LRP/LR impedes telomerase activity.

Naidoo, K.; Malindisa, S.T.; Otgaar, T.C.; Da Costa Dias, B.; Ferreirra, E.; Reusch, U.; Knackmuss, S.; Little, M.; Weiss, S.F.T.; Letsolo, B.T. (Public Library of Science., 2015-11-06)

Cancer has become a major problem worldwide due to its increasing incidence and mortality rates. Both the 37kDa/67kDa laminin receptor (LRP/LR) and telomerase are overexpressed in cancer cells. LRP/LR enhances the invasiveness ...
Unveiling the micronome of cassava (manihot esculenta crantz).

Rogans, S.J.; Rey, C. (Public Library of Science., 2016-01-01)

MicroRNAs (miRNAs) are an important class of endogenous non-coding single-stranded small RNAs (21-24 nt in length), which serve as post-transcriptional negative regulators of gene expression in plants. Despite the economic ...
The persistence and ecological impacts of a cyanobacterium genetically engineered to express mosquitocidal Bacillus thuringiensis toxins.

Ketseoglou, I.; Bouwer, G. (BioMed Central Ltd., 2016-05-10)

Background: The cyanobacterium Anabaena PCC 7120#11 has been genetically engineered to act as a delivery vehicle for Bacillus thuringiensis subspecies israelensis mosquitocidal toxins. To address ecological concerns about ...
Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy

Monchusi, B.; Ntwasa, M. (Public Library of Science, 2017-08)

The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in ...

Browsing School of Molecular & Cell Biology by Issue Date

Browsing School of Molecular & Cell Biology by Issue Date

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